A COMPARATIVE STUDY ON SAFETY PROFILE AND EFFICACY OF FONDAPARINUX AND ENOXAPARIN IN PATIENTS WITH ST- SEGMENT ELEVATION MYOCARDIAL INFARCTION AT TERTIARY CARE HOSPITAL IN KURNOOL

Abstract

Objective: A study was conducted to evaluate and compare the cost-effectiveness of telmisartan and hydrochlorothiazide compared with clinidipineand metoprolol in reducing blood pressurebyone mm of Hg per day in hypertensive patients.

Materials and Methods:It was a prospective experimental analysis of cost-effectiveness, to compare the cost of telmisartan( 40 mg), hydrochlorothiazide(12.5 mg) and cilnidipine( 10 mg) and metoprolol( 50 mg) in hypertensive cases using either of themedicines. An aggregate of 98 casesrecently detected hypertensive cases were considered for the comparison, of which 49 cases were specified telmisartan, hydrocholorithazide and the other 49 were specified cilidipine, metoprolol asper therecommended dosage. Data were analysed using paired and unmatched T-tests in MS- EXCEL soft earthenware.

Results:Thecostofreducing1mmofHgbloodpressureperdaywithtelmisartan,hydrocholorithazide was0.21( SBP),0.31( DBP) INR, whereas that of cilidipine, metoprolol was 0.23( SBP),0.28( DBP) INR. Conclusion:ThispharmacoeconomicanalysisshowsthatTelmisartan,Hydrochlorothiazideisfurthercost- effective as compared to Cilnidipine, Metoprolol succinate whenthe costper reduction inbloodpressure per dayisconsidered.Thismayaffectthecaseseconomicallyduringtheirlong-termuseofthesemotesforthe hypertension