The Green Synthesis of Silver Oxide Nanoparticles and Chitosan-Based on Silver Oxide Nanocomposite for Targeted Treatment of Invitro Anti Diabetic Activity

Abstract

This study aimed to evaluate and compare the anti-diabetic effects of silver oxide nanoparticles (Ag₂ONPs) and chitosan-silver oxide nanocomposite (CS-Ag₂O NC). The nanoparticles and nanocomposite were made using a green synthesis technique, and their anti-diabetic activities were evaluated using in vitro models. The results showed that the CS-Ag₂O nanocomposite had a stronger anti-diabetic effect than Ag₂ONPs due to improved glucose absorption, insulin sensitivity, and alpha-glucosidase inhibition. The nanocomposite also showed reduced toxicity and improved biocompatibility. The study concludes that CS-Ag₂O NC exhibits potential as a material for the development of anti-diabetic drugs. Infrared spectroscopy (FTIR), X-ray diffraction (XRD), EDAX analysis, and UV-vis spectroscopy were used to characterise the nanoparticles and nanocomposite. According to the findings, CS-Ag₂O NC and significant Ag₂ONPs had great anti-diabetic potential.