SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL EVALUATION OF BENZOTHIAZOLE-CONJUGATED PYRIMIDINES DERIVED FROM 2-AMINOACETOPHENONE AS POTENTIAL ANTITUBERCULAR AND CYTOTOXIC AGENTS.

Abstract

The present study aims to synthesize and characterize benzothiazole conjugated pyrimidines as potential anti-tubercular and anti-cancer agents.We have attempted to synthesize and characterize a series of benzothiazole analogs from the key intermediate 1-(2-aminobenzo[d]thiazol-4-yl)ethanone (I). In this process we have synthesized 14 new hybrids (PR1-PR14) were appropriately established by melting point, IR,NMR, mass spectroscopic and analytical data. These compounds were further subjected to their in vitro antitubercular activity using Mycobacterium tuberculosis H37Rv strain and to evaluate their in vitro cytotoxicity potential using colon and breast cancer cell lines. Finally, to identify the ‘in silico hit’ against validated anticancer and antitubercular drug targets for further exploitation using molecular docking simulations molecular modeling studies were performed to ensure the anti-tubercular and cytotoxic activity of the compounds to explore their enzymatic inhibitory activities.