SYNTHESIS, ANTICANCER ACTIVITY AND MOLECULAR DOCKING STUDY OF SOME NOVEL THIAZOLE INCORPORATED SEMICARBAZONE DERIVATIVES

Abstract

Thiazole-based semicarbazone derivatives have garnered significant attention in medicinal chemistry due to their diverse pharmacological properties, particularly anticancer potential. In this study, we report the synthesis, characterization, and biological evaluation of novel thiazole-incorporated semicarbazone derivatives. The synthesized compounds were characterized using spectroscopic techniques such as NMR, and mass spectrometry. Their anticancer activity was evaluated against selected cancer cell lines using MTT assay, revealing promising cytotoxic effects in comparison to standard anticancer drugs. Molecular docking studies were conducted to investigate the binding interactions of these derivatives with key oncogenic targets, providing insights into their mechanism of action. Additionally, drug-likeness properties were analyzed to assess their pharmacokinetic feasibility. The findings suggest that these novel derivatives exhibit potent anticancer activity and favorable drug-like properties, making them promising candidates for further development in cancer therapeutics.