Role of HBVs Ag and INF-gamma Levels on the Progression of Chronic Hepatitis B type

Abstract

       Over 350 million people in the world are chronically infected with the hepatitis B virus (HBV), and 35–40% of them will develop progressive liver diseases such as liver cirrhosis and eventually hepatocellular carcinoma. All chronic HBV carriers, especially those without clinical symptoms, are permanent sources of HBV infection and impose an immense threat to society. This study aimed to evaluation the levels of  HBs Ag, Anti-HB core Ag and INF-gamma and Studying Role of HBVs Ag  and INF-gamma Levels on the Progression of Chronic Hepatitis B  and study the correlation between HBsAg and INF-γ in chronic hepatitis B. Serum of patients ,and the results showed there is a highly significant difference(P<0.001) in of  HBs Ag, Anti-HB core Ag  and INF-gamma and control group and the correlation between IFN-γ and HBsAg show  there is a significant negative weak correlation between IFN-γ and HBsAg levels and the correlation coefficient was (r=-345, p=0.006). This can be interpreted as the body responding to the infection by increasing IFN-γ production, which helps reduce the viral load.