The Function Of The Epigenome And Microbiome In Controlling The Progression Of Endocrine-Mediated Inflammatory In Obesity Due To Diets

Abstract

The role of microbiomes, also known as epigenomes, in metabolic health and inflammation in diet-induced obesity (DIO) has recently been shown by new research. This work explores the interaction between DIO, the epigenomic landscape, and the makeup of the microorganisms in the digestive tract within the setting of endocannabinoid-mediated inflammatory control in a mouse model. Researchers were able to examine the effects of a high-fat diet (HFD) by making C57BL/6J mice gain weight and then monitoring their progress. Determining if there were alterations in metabolic parameters or inflammatory indicators was the primary objective. Epigenetic profiling and genome sequencing allowed researchers to find obesity-related changes in DNA methylation patterns. The mutations were more pronounced in genes involved in inflammation and lipid metabolism. At the same time, researchers found that the HFD was associated with substantial changes in the diversity and composition of gut microbiota when they used 16S rRNA sequencing. Specifically, researchers found more microbial taxa that promote inflammation, which is linked to higher amounts of endogenous cannabinoids. To identify the pathways, scientists used pharmacological treatment to alter endocannabinoid signaling and then studied the resulting metabolic and inflammatory effects. Inflammation in DIO is influenced by both the microbiota and the epigenome, as previously shown. Then, this influences the signaling of endogenous cannabinoids. While further study is required to clarify the precise processes at play and their relevance to obesity prevention and treatment, the present study does draw attention to the intricate relationship between the microbiome, nutrition, and epigenetic pathways as they pertain to metabolic health, as well as the possibility of using these pathways as therapeutic targets for the inflammation that accompanies obesity.