Phytochemical Evaluation, Chromatographic Screening,Biological Evaluation of Antioxidant and Antidiabetic activity of Sesbania grandiflora

Abstract

A vegetable is the classification that is given to the species Sesbania grandiflora, which belongs to the family Fabaceae and is consumed on a regular basis by people in Indonesia. Studies have demonstrated that the secondary metabolites that are found in these plants have the ability to perform a variety of biological functions, including anti-cancer, anti-cancer, anti-bacterial, and anti-diabetic properties. In order to accomplish the objectives of this study, the stembark of Sesbania grandiflora was subjected to a phytochemical analysis by means of Thin Layer Chromatography (TLC), and the results of such an analysis were presented.These compounds are often associated with significant biological activities and contribute to the therapeutic potential of the plants. Total phenolic content was quantitatively assessed in the methanolic extracts, revealing values of 50.72% w/w for Sesbania grandiflora. Phenolic compounds are known for their antioxidant properties, which are largely influenced by their molecular structure, the availability of phenolic hydrogens, and their ability to stabilize the resulting phenoxyl radicals through hydrogen donationwhich is implicated in various chronic diseases.This antioxidant potential is significant, as reactive oxygen species (ROS) contribute to cellular damage and inflammation, linking oxidative stress to a range of pathological conditions.The potential antidiabetic effects of Sesbania grandiflora were evaluated in alloxan-induced diabetic models. This effect is likely due to multiple mechanisms, including the enhancement of peripheral glucose utilization and reduction of intestinal glucose absorption. the findings highlight the potential of these plant extracts in managing diabetes, particularly in populations where traditional remedies are preferred.