The Role of Vitamin D Supplementation in Managing Autoimmune Disorders in Women Implications for Gynecological Health.

Abstract

Background: The function of vitamin D in the human body was found to be critical for immune regulation, and the deficiency in vitamin D has been seen to cause several autoimmune diseases; most gynecological conditions often affect women. Thus, growing evidence shows that vitamin D might be effective for immunological disorders including SLE, RA and thyroid autoimmune diseases. This paper focuses on the impact of vitamin D administration on inflammation in autoimmune disease female patients to better understand better patient outcomes as well as gynecological implications.

Objectives: To assess the effect of vitamin D on disease activity in female autoimmune disease patients and to establish possible advantages of vitamin D in managing gynecologic health extenuated autoimmune complications.

Study design: A Cross sectional study.

Duration and place of study. The department of  Obs & Gynae and Surgical Unit from jan 2023 to Dec 2023

Methods: 150 women of childrearing age with a doctor’s diagnosis of an autoimmune disease: SLE, RA, or autoimmune thyroid disease. Participants were divided into two groups: One group of patients was given 1000 IU of vitamin D daily while the others were not. DAS at 28 and vitamin D at baseline and after One Year  of intervention were compared. Scoring systems were used according to SLEDAI for SLE and DAS28 for RA; results were analyzed by SPSS version 24.0.

Results: 150 women consumers of vitamin D had lower disease activity scores than the control group. The mean SLEDAI score reduction for SLE was 2.3 ± 0.7 in the supplemented group, and 1.0 ± 0.6 in the controls (p=0.03). DAS28 was reduced in RA patients at the end of supplementation 1.5 ± 0.3 in the supplemented group compared with controls 0.7 ± 0.4 (p = 0.02). The level of standard deviation for disease activity was relatively low, 0.6 in the supplemented group and 0.8 in the control group, indicating that vitamin D helps to reduce the variability of the disease.

Conclusion: vitamin D supplementation modulated autoimmune disease activity: implications for gynecologic disorders. It is important to learn how to maintain normal serum vitamin D concentrations in order to better treat autoimmune diseases, enhance the patient’s quality of life and strengthen the immune response. This indicates that predicting and attending to the needs of vitamin D could turn out to be a routine for females with auto-immune diseases.