Comparison of Quality of Life Between Young Onset and Late Onset Parkinson's Disease

Abstract

Background & purpose: Parkinson's disease (PD) is a neurodegenerative disorder and impair different dimensions of quality of life (QoL). The impact of Parkinson's disease on QoL may vary depending on age as onset. Knowledge regarding impact of Parkinson's disease on QoL is limited. Appropriate address dimensions of QoL. may improve QoL in PD patients. Our study is aimed to compare quality of life between young onset Parkinson's disease (YOPD) and late onset Parkinson's disease (LOPD).

Materials and Methods: This study was cross-sectional in nature and involved all PD patients at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, both indoor and outdoor movement disorder clinics. A total of 122 samples were gathered during the course of the study period in order to assess the quality of life between patients with YOPD and LOPD. SPSS version 26 software was used to analyse the gathered data. Appropriate statistical instruments, such as the student's t-test, the chi-square test and Mann Whitney U test were used to do statistical analysis. P values less than 0.05 were considered statistically significant.

Result: In this study we enrolled 122 PD patients (61 YOPD & 61 LOPD). The QoL was lower in our study for patients with YOPD, and there was a significant difference in the self-care (p<0.003) and anxiety/depression (p<0.001) domains. Furthermore, a noteworthy distinction was also demonstrated by the Health State Visual Analogue Scale (p<0.001), indicating that those with a YOPD had a lower overall quality of life. Patients with Parkinson's disease who live in rural locations have a lower quality of life, experience comorbidities, face wearing off, and have advanced Parkinson's disease.

Conclusion: YOPD had a worse quality of life than those with LOPD and commonly experience depression.