Synthesis of Some Novel Derivatives of 1,3,4-Oxadiazole, as Analgesic and Anti-inflammatory Agents

Abstract

1,3,4-Oxadiazole derivatives are found to have a wide range of pharmacological activities and attracting the researchers to work on this nucleus. In this continuation of work a series of novel 1,3,4-oxadiazole derivatives were designed, synthesized and evaluated for analgesic and anti-inflammatory activity. The synthesis of target compounds was performed by reaction of 2-furoic carbohydrazide (FH) or toulic hydrazide (TH) with different carboxylic acid in presence of phosphorous oxy chloride. The synthesized compound Oxa-14 exhibited the most potent analgesic and anti-inflammatory activity.