Development and in-vitro Evaluation Of Polyherbal Nanosuspension For Anthelmintic Activity

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Rakesh Tirkey, Suman Shrivastava, Madhulika Pradhan, Dhansay Dewangan, Vaibhav Tripathi, Vijay Kumar Lahare, Atul N. Chandu, Swarnlata Saraf

Abstract

Objective The aim of the present study is to investigate the anthelmintic potential of polyherbal nanosuspension using extracts of Aegle marmelos (root), Calotropis procera (root), and Rauvolfia serpentina (root) on Pheretima posthuma. MethodsExtracts of selected plant materials were prepared by Soxhlet method and then evaluated for phytochemicals such as flavonoid, tannin, steroids, and alkaloid etc. Then, a polyherbal nanosuspension was formulated from the extracts by employing the antisolvent precipitation technique. Polyherbal nanosuspension and extracts were examined for their anthelmintic efficacy on adult Indian earthworm (Pheretima posthuma) and Mean ± SEM values were estimated for extracts, polyherbal nanosuspension and the standard. Results & ConclusionThe findings showed that, in comparison to the individual extracts, the polyherbal nanosuspension containing chosen plant extracts produced a shorter paralysis time and mortality time in anthelmintic screening. The polyherbal nanosuspension exhibited considerable anthelmintic effect (P<0.05), whichrecommending that the polyherbal nanosuspension could be more effective in treating helminthiasis

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