Design, synthesis, characterization and evaluation of anticancer activity of thiadiazole derivatives

Abstract

Cancer cells start to grow out of control and form new, abnormal cells. Cancer cells can also invade other tissues. Cancer is a world most threaten problem, therefore the development of potent anticancer agents is the urgent need of society. Compounds with heterocyclic nucleus showed potent anticancer activity, in this continuation of work we designed a series of newer derivatives containing thiadiazole heterocyclic scaffold as potent anticancer agent. All the derivatives were synthesized, characterized for their structure identification and evaluated for anticancer activity. The anticancer activity was evaluated against MCF-7 cancer cell lines by MTT assay. The comp A4 showed the highly potent anticancer activity against MCF-7 breast cancer cell line with IC₅₀= 38.59 ± 4.4. The structure activity relationship study revealed that the thidiazole ring is essential for anticancer activity and the substitution of electron withdrawing group at R₁ position exhibited more potent activity against breast cancer cell lines. Methyl group at R₂ and R₃ position showed more potent activity compared to unsubstituted ring.  The results of in silico ADMET properties revealed that all the synthesized derivatives not violated any rules of Lipinski and all are drug like compounds. Overall activity result revealed that these derivatives will be used in future as lead molecules for development of anticancer agents.