Development, Standardization And Pharmacological Screening Of Nanogel Herbal Formulation

Abstract

This study investigates the formulation, evaluation, and characterization of saffron extract-based gels, emphasizing their organoleptic, physicochemical, and phytochemical properties. Saffron, a prized botanical with rich sensory attributes, was explored for its chemical composition, including the presence of compounds such as steroids, triterpenoids, saponins, tannins, and proteins. The formulation process involved blending saffron extract with various excipients, including Tween 80, Carbomer 934, and Polyvinyl alcohol, across ten different formulations (S-1 to S-10). These formulations were evaluated for key attributes such as pH, spreadability, texture, homogeneity, and stability. Results indicated that formulations S-1, S-3, S-4, S-7, and S-10 exhibited slightly heterogeneous properties, with pH values ranging from 5.5 to 6.1, and required further refinement for improved consistency. The findings highlight the complexity of creating a stable and effective saffron gel formulation, while emphasizing the importance of continuous refinement to achieve the desired quality and performance. The study contributes valuable insights into saffron's potential as both a therapeutic and cosmetic agent, advocating for further optimization in gel formulation to unlock its full potential.