Differences In Immunological Parameters Of Synovial Fluid In Patients With Rheumatoid Arthritis, Depending On The Serological Variant And Stage Of The Disease.

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Aripova T.U., Suyarov A.A., Kireev V.V., Ziyadullaev Sh.Kh., Khatamov H.M.

Abstract

 Materials and methods. We examined 21 samples of SF in RA. 11 patients had a late stage of the disease, and 10 patients had an early stage. Leukocytes, relative and absolute values of lymphocytes, CD3, CD4, CD8, CD16, CD20, CD23, CD25 and CD95 were determined in the SF. The determination of lymphocyte subpopulations was carried out by the method of monoclonal antibodies. To determine the normative values of subpopulations of lymphocytes of a healthy person, we have developed a mathematical calculation of the values of subpopulations of lymphocytes of a healthy person (theoretical norm).


Results and discussion. There are significant differences in the relative index of CD3%, CD20% and CD25% between seropositive and seronegative variants of RA (p<0.05). Significant differences in the relative indices of CD4% and CD8% between the early and late stages of RA (p<0.05) are revealed. There is an increase of tens and hundreds of times in the relative and absolute indices of lymphocyte subtypes compared with the normal values, which is associated with the migration of lymphocytes to the focus of inflammation.


Conclusion: Significant differences in a number of relative indicators between the stages and serological variants of the disease are revealed in the SF in RA patients, and at the same time a multiple (tens and hundreds of times) increase in all lymphocyte subpopulations is revealed.

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