Evaluation of Hepatoprotective Activity of Siddha Formulation Arithrathi Chooranam

Abstract

Background: Arithrathi Chooranam is a herbo-mineral preparation used in Siddha medicine, traditionally recognized for its effectiveness in treating jaundice and various hepatic disorders. Despite its historical use, scientific validation of its hepatoprotective mechanisms has been limited.

Aim: This study aims to assess the hepatoprotective properties of Arithrathi Chooranam against liver damage induced by the anti-tuberculosis drugs rifampicin (RIF) and isoniazid (INH).

Materials and Methods: We utilized a rat model of drug-induced hepatotoxicity, administering daily doses of 100 mg/kg of RIF and INH over a period of 21 days. The protective effects of two different concentrations of Arithrathi Chooranam (200 mg/kg and 400 mg/kg) were evaluated alongside the RIF and INH treatment.

Results: The Siddha formulation exhibited significant hepatoprotective activity, effectively reducing liver damage caused by INH and rifampicin. Our findings provide empirical support for the traditional medicinal claims regarding Arithrathi Chooranam's role in managing hepatic toxicity.

Conclusion: This study offers substantial scientific validation for Arithrathi Chooranam as a traditional Siddha medicinal formulation, highlighting its impressive hepatoprotective properties against drug-induced liver damage. While the results are promising, further research is essential, including in-depth studies on molecular mechanisms, comprehensive clinical trials, and the identification of specific bioactive compounds.