Hepatoprotective Activity Of Aqueous Seed Extract Of D. Hamiltonii Against CCI4-Induced Liver Damage In Rats

Abstract

The hepatoprotective effect of  D. hamiltonii aqueous seed extract was evaluated against carbon tetrachloride (CCl₄)-induced hepatotoxicity in rats. Pretreatment with the extract (50–200 mg/kg) significantly reduced serum levels of ALT, AST, ALP, and bilirubin compared to the CCl₄ control. The 200 mg/kg dose provided 71.85% ALT and 69.22% AST protection, nearing the efficacy of standard drug silymarin. These findings highlight the potential of D. hamiltonii as a hepatoprotective agent, likely due to its antioxidant and anti-inflammatory constituents such as flavonoids and polyphenols.