Development and Formulation of Nanostructured Zein Based Drug Delivery System for Sorafenib Tosylate

Abstract

Nanotechnology, specifically the production of nanoparticles, has attracted unprecedented attention from various scientific fields. Nanoparticles can be tailored for targeted drug delivery, enhance bioavailability, and offer a controlled release of medication from a single dose. The size, hydrophobicity, hydrophilicity, and surface charge distribution of polymeric nanomedicines all affect their capacity to reach the target organ. Zein, a protein found in maize kernels, has special thermoplastic and hydrophobic qualities that set it apart from other proteins. It has been commercially available since 1938 and has a variety of industrial uses. Here an antisolvent nanoprecipitation method was used for the formulation of the zein based nanoparticle of Sorafenib. Where the organic phase was constituted with ethanol and the aqueous or antisolvent phase was deionised water with pluronic and PVA. With the help Box-Behnken design the formula of final preparation was optimized.