Design, Evaluation Optimization Of Oro Dispersible Film Of Valsartan Using Response Surface Method: In Vitro Characterization

Abstract

The present work aimed at preparing quick release films of Valsartan with the purpose of developing a dosage form for a very quick onset of action, which is beneficial in managing of hypertension, aiding in the enhancement of bioavailability, and is very convenient for administration, without the problem of swallowing and using water.Valsartan Oro dispersible films prepared by using solvent casting technique by using different film forming polymers.All prepared films were evaluated for its weight variation, disintegrationtime, thickness, drug  content, pH,  dissolution  study,  and  folding  endurance.  The drug-excipients compatibility study  was  done using differential scanning calorimetry (DSC) and Fourier transform infrared (FTIR). DSC and FTIR showed no interaction between the Drug and polymers. Formulation F3 is considered as the optimized formulation as it showed good folding endurance (>300), faster disintegration rate (32 s), and maximum in vitro drug release (98.36%) within 30 min. Fast oro dispersible films of valsartan can be considered suitable for clinical use in the treatment of hypertension, where a quicker onset of action for a dosage form is desirable along with the convenience of administration.