Formulation And Evaluation Of Solid Dispersion For Enhance The Solubility Of Atovaquone

Abstract

The aim and objectives of this present work are based on application of various nanotechnology based strategies to achieve the objectives of improved solubility, dissolution rate and oral bioavailability. Atovaquone is an anti-malarial agent and belongs to biopharmaceutical classification system class IV. The polymers like PEG 4000, PVP K30 were used for solid dispersion. For preparation of solid dispersions, various solid dispersion methods (Solvent evaporation, Fusion method) were used. The effect of several variables to both solid dispersion preparations was investigated. IR and UV spectral analysis, Differential Scanning Calorimetry were used to characterize solid dispersions. Solid dispersions prepared by various methods were evaluated by methods like Saturation solubility, percent drug content, and by in -vitro dissolution method for percent cumulative drug release. Optimized solid dispersions were further evaluated by XRD, DSC, and SEM.