Formulation And Evaluation Of Solid Dispersion For Enhancement Of The Solubility Of BCS Class II Drug

Abstract

The aim of this present work is based on application of various nanotechnology based strategies to achieve the objectives of improved solubility, dissolution rate and oral bioavailability of Itraconazole. The drug with poor water soluble present challenges during dosage form design due to their inadequate solubilization in digestive fluids. So in order to overcome problems associated with poor water soluble drugs there is need to improve their solubility. Itraconazole is an imidazole/triazole type antifungal agent. Itraconazole is a highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethylation via the inhibition of the enzyme cytochrome P450 14α-demethylase and belongs to biopharmaceutical classification system class II. Polymers such as PEG 4000 and HPMC were used for solid dispersio Solvent n. For preparation of solid dispersions, various solid dispersion methods (evaporation, Fusion method) were used. The effect of several variables to both solid dispersion preparations was investigated. IR and UV spectral analysis, Differential Scanning Calorimetry were used to characterize solid dispersions. Solid dispersions prepared by various methods were evaluated by methods like Saturation solubility, percent drug content, and by in -vitro dissolution method for percent cumulative drug release. Optimized solid dispersions were further evaluated by XRD, DSC, and SEM.