Natural Enzymatic and Regenerative Therapy Using Papaya and Honey: Case Report of Chronic Burn Healing and Potential Role in Radiation-induced Dermatitis

Abstract

Chronic partial-thickness burns frequently require surgical intervention due to delayed healing. Natural agents such as Carica papaya and honey possess enzymatic, antimicrobial, and tissue-regenerative properties that may support conservative wound care. This case report describes complete healing in 28 days of a chronic second-degree thermal burn using a sequential papaya–honey dressing protocol, avoiding previously recommended surgical debridement and grafting. An integrated Unani perspective is provided to contextualize the therapeutic actions of honey and papaya within traditional wound-healing principles. Additionally, the potential application of this technique to radiation-induced dermatitis (RID) is discussed, supported by mechanistic insights and existing clinical literature