Mapping the Global Research Status and Trends on Mesenchymal Stem Cell–Driven Tissue Engineering for Hand Reconstruction: A Bibliometric Study

Abstract

Introduction:

Reconstructing the hand remains a clinical challenge on account of complex hand anatomy and restoration of both structural stability and fine motor function. While conventional surgical techniques can restore anatomical structures, they often fail to accomplish true biological regeneration. Tissue engineering based on mesenchymal stem cells (MSCs) has therefore become an effective regenerative treatment approach for bone, tendon, cartilage and soft tissue defects of the hand. This study aimed to conduct a bibliometric analysis of the research trends and knowledge structures of MSC-based tissue engineering for hand reconstruction globally.

Methods:

A bibliometric analysis using publications obtained from Scopus and PubMed databases. A systematic search strategy using keywords related to mesenchymal stem cells, tissue engineering and hand-related musculoskeletal tissues was used. After screening and assessment of eligibility, 300 peer-reviewed articles were included. Publication trends, citation performance, top countries and institutions in this area, collaboration networks and keyword co-occurrence were studied using bibliometric tools.

Results:

The study showed a gradual rise in scientific output over the last twenty years, with a noticeable speedup in the past ten. Research activity was mostly located in countries with robust translational research infrastructure and interdisciplinary integration. Major research domains encompassed scaffold fabrication, biomaterial innovative developments, tendon and cartilage regeneration, and growth factor–mediated target pathways of signal transduction, indicating a full current trajectory toward translational relevance and early clinical translation.

Conclusion:

Mesenchymal stem cells (MSCs) based tissue engineering studies for hand reconstruction have seen rapid increase over the past years. This bibliometric analysis identifies significant research trends, collaboration dynamics, and potential future directions that can guide further scientific endeavors toward the development of regenerative therapies for complex hand injuries