Preventive potentials of Agada Yoga in Necrotic Effect of Pit Viper Envenomation: An open label, single arm clinical study

Abstract

Pit viper envenomation leads to local tissue damage, particularly necrosis of skin, has become more significant problem. Sigru sireeshadi Yogaas Lepaalong with Lodhra sheethadi Kashaya pana arementioned in Prayogasamuchaya and Visha Vaidya Jyothsnika respectively found clinically effective in treating Mandali sarpa Damsha w.s.r. to Pit viper envenomation and found effective in preventing necrotic effect in post envenomation, but scientifically not proved. Hence the present study was planned to evaluate the combined effect of Sigru sireeshadi YogaLepa andLodhra seethadi Kashaya pana in prevention of necrotic effect in Mandali sarpa Damsa w.s.r to pit viper envenomation.

METHODOLOGY:  An open labelled, single arm clinical study with the history of Mandali sarpa Damsa w.s.r to pit viper envenomation was planned. Total 30 subjects satisfying diagnostic criteria were selected by convenient sampling method from OPD & IPD of Papinissery Visha Chikitsa Kendra, Kannur District, Kerala. Sigru sireeshadi Yoga was applied as Lepa 6 th hourly and Lodhra seethadi Kashaya pana 15 ml bdwas administered orally for three days. Standard scoring of cardinal symptoms was used to measure the efficacy of treatment before and after. Statistical analysis was done by using student’s paired t- test.

RESULT: The study showed statistically significant effect with P<0.001 in cardinal symptoms likeOedema (95%), Erythma (81%), Pain (95%) and Burning sensation (85%).

CONCLUSION: The combined effect of Sigru sireeshadi YogaLepa and Lodhra seethadi Kashaya pana in effective in prevention of necrotic effect in Mandali sarpa Damsa w.s.r to pit viper envenomation.