Relationship between Cardiac myosin binding protein–C with traditional risk factors in early diagnosis of acute coronary syndrome patients

Abstract

Background: Coronary heart disease (CHD) is primarily caused by atherosclerotic lesions within the intima of coronary arteries and acute coronary syndrome (ACS) is the main acute clinical manifestation of CHD. The ACS is manifested in one of three subtypes and is still one of the main causes of morbidity and mortality worldwide. Early diagnosis of ACS and of MI, in particular, is important in decreasing mortality in ACS patients. Few risk factors were established as factors that increase risk of CHD while many have emerged and need to be established.

Objective: To investigate relationship between cardiac myosin binding protein–C with traditional risk factors for acute coronary syndrome patients in early diagnosis.

Subjects & Methods:One hundred twenty patients (72 males and 48 females), aged ≥ 30 years were consecutively selected from those who were admitted to emergency department (ED) of Al-Yarmouk teaching hospital and diagnosed as ACS by specialist cardiologists. The ACS patients constituted three subgroups according to the subtype of ACS; namely the STEMI, NSTEMI and UA group.The duration between onset of chest pain and admission to ED should not exceed three hours in any selected patient. Apparenty healthy subjects as controls group. For each study subject, cMybp-C serum levels was measured using enzyme linked immunosorbent assay kits. For each ACS patient, serum level of FBS,GOT and cholesterol were measured by COBAS 111fully automated device.

Results:The cMybp-C serum level remained significant higher level in presence or absence of any of the studied risk factors in (STEMI and NSTEMI) subgroups,while non-significant increase in UA subgroup with or without risk factors .The cMybp-C mean level showed an overall significant difference among study groups, cMybp-C mean level was significantly higher in each ACS subgroup than in controls group (P < 0.001).

Conclusion:The study found that risk factors do not have an effect on the biochemical marker cMybp-C,but they do have an effect on increasing the prospect of coronary heart disease, which will lead to change in the concentrations of the biochemical marker.That is, the effect is indirect. So cMybp-C serum level remained significant higher level in presence or absence of any of the studied risk factors