Impact of Obesity on Pulmonary Function in Asthmatic Patients: A Comprehensive Systematic Review and Meta-Analysis

Abstract

Obesity and asthma are two major global health concerns with significant socioeconomic burdens. Emerging evidence suggests that obesity worsens asthma control and pulmonary function, although the exact mechanisms remain unclear. This systematic review and meta-analysis aim to investigate the impact of obesity on lung function in asthmatic patients by analyzing existing clinical studies and experimental findings. We will provide insights into underlying mechanisms, inflammatory pathways, and discuss how obesity-related comorbidities exacerbate asthma symptoms. Additionally, we propose updated clinical guidelines to improve asthma management in obese populations. Our findings underscore the need for personalized, multidisciplinary approaches to treat this comorbid condition.