Evaluation of the levels of the Lipid profile in patients with polycystic ovaries and insulin resistance

Abstract

Background: High levels of male hormone, irregular menstruation, hormone imbalances, and metabolic abnormalities are the diagnostic criteria for polycystic ovarian syndrome, a common endocrine condition that affects 6 to 20 percent of women of reproductive age. An imbalance in the quantity of insulin secreted is known as insulin resistance, and it increases the risk of heart disease and type 2 diabetes. 

Objectives: Evaluate the Lipid profile (LDL, HDL, triglyceride and cholesterol) in the serum of those with insulin resistance and polycystic ovarian syndrome and its comparison with the control group.

Materials and Methods: Eighty women between the ages of 16 and 40 are included in a case and control study. Forty of the first group, who had polycystic ovarian syndrome and insulin resistance, were matched with forty healthy women in the second group. October 2023 and February 2024 were the dates of sample collection for each. The lipid profile was analyzed as follows.

Results: The results of the study demonstrated a difference in the biostatistics of the lipid profile (LDL, HDL, triglyceride, and cholesterol) between the PCOS and IR group and the control group. Additionally, when the patient group was compared according to age, the study demonstrated the impact of the patient's woman's body mass index (BMI).

Conclusions: It was discovered that patients with PCOS and IR had greater levels of LDL, HDL, triglyceride, and cholesterol than the control group. Additionally, the data indicated that patients older than 30 had significantly higher levels of both LDL and cholesterol. The BMI is highly significant, and among the patients, obesity accounted for 45% of the group's characteristics.