Diuretic Effect of Hydro Alcoholic Extract of Allium sativum and Occimum Basilicum and its Phytochemical Studies

Abstract

Introduction: Diuretics can help with some medical disorders, including as hypertension, decreased fluid retention, edema, inflamed ankles, and pain. Due to the global trend towards the use of natural plant remedies, information about the features and applications of medicinal plants is in great demand.

Aim: For the aforementioned reasons, the present investigation’s objective is to assess the diuretic efficiency of the hydroalcoholic extract of Allium sativum and Occimum basilicum.

Methodology: Five grams of dried plant were coarsely pulverized and extracted with ethanol and water. After filtration, each aqueous extract was used. The hydro-ethanolic extract of Allium sativum (bulb) and Occimum basilicum (leaves) is investigated in terms of histopathology and diuretic efficacy.

Result: When compared to zero days, the aforementioned parameters—creatinine, urea, and glucose—do not change during the seven-day treatment. Smaller biochemical changes were observed between the 15th and zeroth days. The hydroalcoholic extracts of Allium sativum and Occimum basilicum also enhanced urinary volume. At 200 mg/kg & 400 mg/kg body weight, the increment was 18% (p < 0.01) & 41% (P < 0.001), respectively, compared to the control group.

Conclusion: This current study will be extremely useful in assessing the diuretic effect of the Allium sativum and Occimum basilicum extracts since it will use ion-selective channel blockage to detect the ions and electrolytes that the animals evacuate.