Study Of The Therapeutic Efficacy Of Pumpkin Seed In Improving The Liver's Activity In Rats With Stz-Induced Diabetes

Abstract

The effect of alcoholic pumpkin seed extract (Cucurbita pepo L.) on metabolic risk, oxidative stress, inflammation, renal function indices, liver death, and histopathological changes in experimentally induced diabetes was investigated. In diabetic rats maintained in an experiment, researchers examined the effects of alcoholic pumpkin seed extract (Cucurbita pepo L.) on liver mortality, renal function indicators, oxidative stress, inflammation, metabolic risk, and histological changes.Male rats were given a single injection of streptozotocin (STZ; 40 mg/kg, i.p.) to cause diabetes. Three months later, the rats received an every-other-day dose of 200 mg/kg of pumpkin seed extract. After receiving pumpkin seed extract treatment, diabetic rats' HbA1c and hyperglycemia improved, as did their insulin, HOMA-IR, and liver function enzyme levels (AST, ALT, and ALP). Additionally, pumpkin seed extract enhanced serum indicators and liver function enzyme activities, normalized serum GSH, CAT, and SOD levels, and decreased elevated levels of MDA and H2O2. These results are supported by histopathological analyses of liver sections, which demonstrate the beneficial effects of pumpkin seeds. According to the current research, pumpkin seeds shield the liver from oxidative stress brought on by diabetes. In summary, pumpkin seeds have a great deal of therapeutic promise for the management of diabetes, including the treatment and control of its liver-related problems.