Design, Synthesis, Molecular Docking, And Biological Evaluation Of Tetrazole Derivatives For Antimicrobial Potential

Abstract

 A series of tetrazol derivatives 1(a-c) and 2(a-c) were synthesized by Mannich base reaction. Synthesized compounds1(a-c), and 2(a-c) were confirmed by IR, ¹H NMR, ¹³C NMR, mass spectral, and elemental analysis. Synthesized compounds 1(a-c), and 2(a-c) were screened for antibacterial and antifungal activity. The compound 1b was highly active against S. aureus in antibacterial screening. The synthesized compounds have been screened for fungal species.  The compounds were synthesized and characterized them, and the structure was confirmed It was revealed that some synthesized derivatives show remarkable biological activity against both gram-negative and gram positive bacterial species and fungal microorganisms. Therefore, current study demonstrates the antibacterial and antifungal activity potential of new tetrazole derivatives and provides future insights for developing antibacterial and antifungal drugs.