In Silico And In-Vitro Screening Of Flavonoids Against Different Pathogenic Microorganisms

Abstract

ABSTRACT: Human health was in grave danger due to antibiotic resistance, and new antimicrobial drugs are urgently needed. Flavonoids, one of the most abundant families of secondary metabolites found in plants, are widely distributed throughout the plant and are becoming more and more well-known for their antibacterial properties. Because it is essential to protein synthesis, the enzyme asparaginyl tRNA synthetase makes a great molecular target. This computer investigation was made possible by evidence from the literature that offered hints for finding flavonoids as possible antimicrobial leads. The potential antimicrobial properties of flavonoids are confirmed by computational factors such docking score, binding energy, intermolecular hydrogen bond interaction, and identical amino acids. The results demonstrate that they can be investigated further.