Preparation, Optimization And Evaluation Of Dexamethasone Film For Inflammation

Abstract

The goal of the current study, which focusses on treating ocular inflammation, is to use ocular films to reduce the frequency of drug administration, achieve controlled release, and increase the therapeutic efficacy of the drug (dexamethasone). According to a factorial design study, multiple combinations containing diverse combinations of polymers, such as HPMC K100M, ethyl cellulose, Carbopol 934, and PVP K30, were designed for different batches of ocular films with a 0.5% w/v concentration via solvent evaporation method. No microbiological growth was discovered in any formulation during sterility testing by direct inoculation method. The drug release for prepared formulations of different batch codes DF1, DF2, DF3, DF4, DF5 and DF6 was found to be 92.6 ± 1.6, 55.1 ± 3.6, 92.3 ± 2.7, 96.1 ± 1.5, 97.9 ± 3.8 & 94.5 ± 4.5 % respectively upto 12 hours. The highest drug release (97.9±3.8) was optimised for ocular films with batch code DF5. Periodically (0.5 to 06 hours) after the sterile formulation was administered, the anti-inflammatory impact was observed in the treated versus control eyes of every rabbit. With just one dose, the inflammation was totally decreased by the optimised batch DF5 of ocular inserts for up to four hours