Formulation And Evaluation Of Zinc Oxide Nanocarriers For Antibacterial Activity

Abstract

ABSTRACT: Zinc oxide nanoparticles were synthesised via polyol-mediated synthesis in this study. Refluxing zinc acetate precursor in diethylene glycol (DEG) and triethylene glycol (TEG) with and without sodium acetate for two and three hours was how the synthesis process was completed. To characterise the antibacterial activity of produced ZnO nanoparticles (ZF1-ZF8) against various bacteria, including Salmonella typhi, Escherichia coli, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus. X-ray diffraction (XRD), UV visible spectroscopy (UV), thermogravimetric analysis (TGA), Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) were used to characterise all of the synthesised ZnO nanoparticles (ZF1-ZF8). Using the agar-well diffusion method, an antibacterial investigation was conducted on both gram-positive and gram-negative bacterial strains. While ZF7 and ZF8 demonstrated higher activity on some strains than others, ZF3 exhibited nearly constant activity on all of the strains. According to the results, ZnO nanoparticles may find use as antibacterial agents; however, the way in which they work depends on surface changes and composition.