Correlation Between Ki67 And Novel Bioscore System (Seer Data Base Analysis) In Predicting The Prognosis Of Breast Cancer

Abstract

Breast cancer is the leading cause of death from cancer for women worldwide.

Proliferation of cells has a major impact on prediction of risk of recurrence, thereby assessment of proliferation is one of the major factors in determining the prognosis of breast cancer. Ki67 is a nuclear protein associated with cellular proliferation.

The SEER (Surveillance, Epidemiology and End Results) database includes the various potential risk factors for breast cancer that are significantly associated with the overall prognosis of breast cancer patients. The Demographic data included the age at the presentation of cancer and the pathological findings included tumour size, axillary lymph node status, tumor histological grade, hormone receptor status.

The purpose of the study is to find out if, just by doing Ki67 alone in a newly diagnosed breast cancer patient, whether we can predict the prognosis. Further prognostic significance of Ki67 pre and post neo adjuvant therapy is to be evaluated in the various types of breast cancer.