Efficacy of High Dose Amoxicillin Therapy in the Eradication of H.Pylori

Abstract

This article provides a comprehensive review of the efficacy of high-dose amoxicillin therapy (HDAT) for the eradication of Helicobacter pylori, with a focus on the variability of outcomes observed across diverse populations. Research indicates that the effectiveness of HDAT may be influenced by regional and genetic factors, highlighting the need for tailored, population-specific treatment strategies. Despite limitations, recent studies report improved eradication rates with HDAT, particularly in regions heavily impacted by antibiotic resistance. However, challenges such as complex treatment regimens, side effects, and patient non-adherence continue to impede global eradication efforts. This article explores the intricate factors influencing H. pylori prevalence and treatment, including the bacterium's role in carcinogenesis and the evolving paradigms in therapeutic approaches. Additionally, advancements in HDAT are discussed, focusing on its pharmacodynamic properties and clinical efficacy. Emphasis is placed on the importance of tailoring therapies to individual patient profiles, advancing personalized medicine. The need for better diagnostic tools, coordinated public health efforts, and innovative therapeutic development is also highlighted, as essential steps toward enhancing global eradication strategies.