Correlation of Circulating microRNA-496 and vascular endothelial growth factor VEGF in triple negative breast cancer

Abstract

Background: Any breast cancer that either lacks or exhibits low levels of the estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) overexpression, and/or gene amplification is referred to as triple-negative breast cancer (TNBC) because the tumor tests negative on all three tests. MiRNAs are essential for governing many cellular and metabolic processes, most notably those that govern cell survival, differentiation, and proliferation.

Objectives: The study was aimed to investigate the correlation of miRNA-496 and VEGF in TNBC pateints compared with healthy indiveduals.

 Methods: Using Real time PCR, micro RNA-496 gene expression was measured in plasma samples and ELISA used to measure VEGF for 40 Triple negative breast cancer patients diagnosed by clinical examination, mammography, ultrasound, and histology are included (Tru-cut)., 40 healthy controls with no history of cancer or inflammatory disorders

 Results: The current study reveal a significant decrease in miRNA-496 gene expression with significant negative correlation to VEGF in TNBC group compared with healthy individuals.

 Conclusions :  Current research result of miRNA-496 in TNBC Suggest it as suppressor for VEGF and  it may also serve as the novel therapeutic target for TNBC in the future.