Assessment of the Role of Insulin Growth Factor Receptor in Angiogenesis, Metastasis, and Prognosis in Oral Squamous Cell Carcinoma by Immunohistochemical study and Real-time PCR

Abstract

Objective: In this study, we investigate IGFR1 expression among OSCC samples suggests a correlation with tumor differentiation. Also, the variability in CD34 expression across different OSCC samples.

Methods: Real-time PCR can be applied for both qualitative and quantitative analysis. Therefore, it has become the method of choice for the rapid and sensitive detection and quantification of nucleic acid in biological samples for many diverse applications such as determination of cancer status.

Results: In this study, Real-time PCR results show that IGFR1 expression is highest in severely differentiated OSCC samples. Poorly differentiated tumors are likely to show higher IGFR1 expression due to the receptor’s role in promoting cell growth and resisting apoptosis, while well-differentiated tumors may show lower levels. Increased CD34 levels are associated with higher tumor grades and more aggressive behavior. Tumors with high CD34 expression and higher IRS values are likely to exhibit a greater potential for metastasis and invasiveness due to the increased microvascular density.

Conclusion: This suggests that as tumors become less differentiated and more aggressive. The present outcomes from this study are going in same way with many documentations. These reports have indicated the role of IGFR1 in angiogenesis, metastasis, and prognosis of OSCC.