Comparison of TNF-α, IL-6 and IFN-γ Proinflammatory Cytokine Levels of COVID-19 Patients in Bengkulu City

Abstract

Coronavirus disease-19 or COVID-19 pandemic was happening all over the world and is the main concern of every country in the context of preventing, handling and controlling the disease, including in Indonesia. Severe Acute Respiratory Syndrome Virus 2, or SARS-Cov 2, is the official name of the virus that causes COVID-19. The virus has a fast and easy transmission rate and can cause death so serious control is needed in prevention and management of COVID-19 disease. Previous studies showed that the level of anti-SARS-CoV-2 IgG antibodies in the patient's body increased from the first week to the third week. Then COVID-19 patients who have recovered still show reactive levels of anti-SARS-CoV-2 IgG antibodies for up to three months after recovery, while antibody levels of anti-SARS-CoV-2 IgM levels are no longer reactive in COVID-19 patients who have been cured. healed. Apart from IgG and IgM, several other components of the immune system are also important to study. The increase in circulating cytokine levels in the patient's body is often referred to as a cytokine storm. According to the findings of several studies, the amount of cytokines, particularly the proinflammatory cytokines IL-6, TNF-α, and IFN-γ, is correlated with the severity of COVID-19 disease. Therefore, this study attempts to analyze the comparison of proinflammatory cytokine levels in COVID-19 patients who are being treated and those who have recovered.