Evaluation the therapeutic efficacy of Cyperus esculentus in reducing kidney and liver injury in rats dosed with atorvastatin

Abstract

Background: Atorvastatin is medication used to lower cholesterol and triglycerides (fats) levels to help prevent heart disease, angina (chest pain), strokes, and heart attacks, belongs to a class of medications called HMG-CoA reductase inhibitors (statins), it's has a nephrotoxicity and hepatotoxicity as a side effects.Studies have shown that cyperus and its bioactive components possess antioxidant, as well as anti-inflammatory, hepatoprotective, and has properties of nephrotoxicity prophylaxis.Aim of study:The aim of our study is to test whether the cyperus extract can exerts a beneficial effect on renal & liver injury. Materials and methods: 24 laboratory rats were used in this experiment, and the animals were divided into four groups, which are the negative control group, the positive control group, the cyperus extract group, and the atorvastatin and cyperus group. At the end of experiment, the samples were used to measure blood urea & creatinine levels (for kidney), AST & ALT enzymes (for liver). Result:The results of this study showed significant positive effect of cyperus extract in reducing the very high levels of hepatorenal enzymes induced by atorvastatin treated group only For the atorvastatin and cyperus treated group, the levels of enzymes return to the close normal levels of the control group which mean the cyperus acts as an antioxidant for the atorvastatin. Also this effect was proved for histological study when cyperus repaired damaged cells and tissues induced by atorvastatin. Conclusions: The results of the current study show the clear therapeutic properties of this plant extract in improving body functions, increasing resistance to diseases, and enhancing immunity through its role in reducing the toxicity of the drug used on liver and kidney functions and returning their vital indicators to their normal levels.