A Study of Antithyroid Peroxidase Antibody and Its Correlation with Polycystic Ovary Syndrome in Reproductive Age Group Women

Abstract

Objective: To find the correlation of thyroid autoimmunity in PCOS women of reproductive age group.

Methods: Study design: prospective study was done at sree Balaji medical college and hospital, Chennai. july 2021- july 2022. Fifty nine cases of reproductive women with PCOS based on Rotterdam's criteria and an equal number of age-matched controls (women without PCOS) were included in the study. Antithyroid peroxidase titre were estimated using chemiluminescence techniques.

Results: Menstrual irregularity (oligomenorrhoea and amenorrhoea) was the most common abnormality found in patients with PCOS compared with non-PCOS (p < 0.0001). Our study shows upper lower class(55. 9%) was statistically significant difference in socio- economic class between groups (p=0.001).

Our study shows that the mean serum levels of anti-TPO antibodies were significantly higher in PCOS patients than in healthy women. The finding denotes the anti- TPO positivity was noted in 25%  of patients with PCOS.

Conclusion: Our study depicts that PCOS was associated with increased anti-TPO titres, thus highlights the importance of screening all PCOS patients for anti-TPO and by adding anti TPO Antibody in the investigation protocol