Case Report: Ossifying Pilomatricoma Masquerading as Calcified Sebaceous Cyst Causing Diagnostic Challenge- A Rare Case Report Histological Insights into Ossifying Pilomatricoma

Abstract

Ossifying pilomatricoma is a rare, intriguing variant of pilomatricoma, distinguished by the formation of bone-like structures in the tumor. It is uncommon and poorly documented with clinical diagnostic challenges. Pilomatricoma, or calcifying epithelioma of Malherbe, arises from hair follicle matrix cells and appears as a firm, painless, subcutaneous nodule in the head, neck and upper extremities of children and young adults. This report presents a case of ossifying pilomatricoma in a 32-year-old female, detailing its clinical presentation, histopathological features, and management. While classic pilomatricoma is characterized by calcification, the ossifying variant is distinguished by its progression to true bone formation, featuring identifiable bony structures within the tumor. Identifying ossifying pilomatricoma is crucial for accurate diagnosis and management, as it influences clinical presentation, imaging, and treatment compared to non-ossifying variants. This report aims to highlight the unique histopathological features of this rare variant to improve treatment options and patient outcomes.