Assessing Insulin Resistance and Metabolic Syndrome Prevalence Among Rural and Urban Adolescents in South India Using HOMA-IR

Abstract

INTRODUCTION: Insulin resistance is a metabolic condition marked by decreased cell sensitivity to insulin, which impairs the uptake and utilization of glucose. It plays a major role in the emergence of a number of metabolic illnesses, such as metabolic syndrome, a collection of risk factors that includes dyslipidemia, high blood pressure, abdominal obesity, and poor glucose metabolism. Teenagers who have metabolic syndrome or insulin resistance should have these conditions identified as soon as possible to avoid long-term health issues and facilitate early treatments. Evaluation of Insulin Resistance and Metabolic Syndrome Prevalence in South Indian Adolescents, Both in Rural and Urban Settings Employing HOMA-IR could provide a number of unique benefits, like as Put Adolescents First. Although a large body of research has been conducted on adult metabolic syndrome and insulin resistance, relatively few studies have focused explicitly on adolescents. This study closes a significant gap by concentrating on teenagers and offering HOMA-IR cut-off values that are particular to their age. This innovative method acknowledges the distinct physiological traits and metabolic profiles of this age group.

Aim: The present study was planned Assessing Insulin Resistance and Metabolic Syndrome

Prevalence Among Rural and Urban Adolescents in South India Using HOMA-IR

Methodology: This study, which was conducted in Sree Balaji Medical College and Hospital in

Chennai between October 2023 and December 2023, employs the homeostatic model assessment for insulin resistance approach. Each participant's parents gave written informed consent for their

ward to participate in the study at the time it was started. Children's consent was also acquired prior to taking blood samples. Every participant had their blood pressure, height, and weight measured. To determine plasma glucose and serum insulin values, blood was collected both before and after the glucose load. BMI was computed. By using the Tanner & White approach, SMR was found. (22,23).

 Result: Adolescents with any component of MS had significantly

higher HOMA-IR values than those without. When both techniques (definition of MS by IDF or HOMA-IR cut-off of 2.5) were combined, the yields for MS were higher:37.5%,68.7%, and 100% in normal, overweight, and obese group, respectively.

 Conclusion: In south Indian

adolescents, HOMA-IR increased with sexual maturity and with progression from normal to obese. A HOMA-IR cut-off of 2.5 provided the maximum sensitivity and specificity in diagnosing MS in both genders as per IDF criteria.