"Ficus Krishnae Extract: A Promising Natural Therapeutic for High-Fat Diet-Induced Obesity in Rats"

Abstract

Objective: The present study aimed to examine the anti-obesity effects of the hydroethanolic extract of Ficus Krishnae (HELEFK) in a high-fat diet (HFD)-induced obesity in rats.

 Methods: HELEFK was administered to rats categorized into six groups: normal control, HFD control, orlistat-treated, and HELEFK-treated (100, 200, 400 mg/kg). Over eight weeks, an HFD-induced obesity model was developed and treatments were administered. In addition, measurements were made of the body weight, BMI, Lee index, feed intake, lipid profiles, antioxidants, and liver indicators. Histological analysis of adipose tissue assessed morphological changes.

 Results: HFD-induced obesity was evidenced by significant increases in body weight, BMI, Lee index, feed intake, fat depot content, and elevated triglycerides, total cholesterol, and LDL levels, along with decreased HDL levels. Oxidative stress was also elevated, as shown by increased TBARS levels and compromised antioxidant and liver markers, with enlarged adipocytes indicating fat accumulation. Treatment with HELEFK at 200mg/kg, and 400 mg/kg significantly decreased body weight, BMI, Lee index, feed intake, and fat depot content in a dose-dependent manner. Furthermore, treatment with HELEFK led to significant decreases in LDL, total cholesterol, and triglycerides, along with increased HDL levels. HELEFK also lowered TBARS levels and improved antioxidant markers and liver function, and decreased adipocyte sizes in the HELEFK-treated groups in comparison to the HFD control, indicating a favourable impact on the shape of fat tissue.

 Conclusion: HELEFK has the potential to reduce HFD-induced obesity and oxidative stress. Its anti-obesity effects may be mediated through its antioxidant properties and potential direct actions on fat tissue morphology