Measurement of TSHER gene expression in patients with hypothyroidism

Abstract

Hypothyroidism (HD) is a common disorder of the Endocrine glands in which the thyroid gland Specifically does not produce enough thyroid hormones. In this study, we addressed Most important functional genes associated with an increased or decreased risk of hypothyroidism. To achieve this goal, we used quantitative PCR-RT based gene expression measurement. The study was conducted on 50 Woman with HD, 50 patients without any chronic diseases were used as a control group. For women with HD, clear clinical features of HD and abnormal results of routine tests of thyroid function were observed. Chemical tests showed an increased concentration of thyroid stimulating hormone (TSH) and low for the hormones T4, T3 in the serum in this group. As for measuring the percentage of lipids in serum, it was observed that lipids were increased percentage of fats (Triglycerides (TG) and cholesterol (CHOL)) in the serum of women with HD. The results of molecular analysis showed a high significance (P≤0.01) of gene expression of TSHER gene for women with HD compared to healthy women.