Siddha Medicine as a Novel Approach to Biofilm Disruption: Current Evidence and Research Prospects

Abstract

Background: Biofilms are surface-attached structured communities of microorganisms, most known for their remarkable resistance to environmental stressors such as antimicrobial treatment. Infections related to biofilms are responsible for life-threatening infections in hospital or community-acquired situations due to persistence of chronic infections and resistance against antibiotics. Conventional therapies often prove inadequate for biofilms, necessitating innovative approaches. Aim: Understanding the biofilm impact of Siddha medicine with potential reference to review article. Methods: This review highlights various natural compounds used in Siddha medicine including Plectranthus amboinicus, Curcuma longa (turmeric), Azadirachta indica (neem), and Padikara parpam against biofilm formation prevention, degradation of existing biofilms, and to potently increase susceptibility towards antibiotics.