Evaluating The Efficacy Of Combining Platelet-Rich Fibrin With Biphasic Calcium Phosphate For Improving Fracture Healing

Abstract

INTRODUCTION:

The global health burden of fractures is substantial, and projections show that the impact on morbidity and mortality is rising. Combining platelet-rich fibrin (PRF) with biphasic calcium phosphate (BCP) presents a viable way to enhance the healing process. The purpose of this study is to assess how well PRF + BCP works to promote fracture healing, especially in the early stages of callus formation.

MATERIALS AND METHODS:

A prospective randomized open-control trial was conducted at Saveetha Medical College over two years, from 2021 to 2023. The study included 26 patients aged 20-70 with upper limb diaphyseal fractures treated with plate osteosynthesis. Patients meeting inclusion criteria were allocated into two groups, with 13 patients in each. Radiological assessments were performed monthly to monitor fracture healing progress.

RESULTS:

The combination of PRF + BCP demonstrated significantly higher levels of callus formation at the 4th and 6th weeks compared to the control group. By the 8th week, 92.3% of cases treated with PRF + BCP exhibited callus formation, while only 46.2% of controls showed similar results by the 12th week.

CONCLUSION:

Adding PRF to BCP significantly promotes early callus formation and accelerates the fracture-healing process. The simplicity of PRF preparation and its autologous nature make it a safe and effective adjunct to orthopedic treatments. The findings underscore the potential of PRF in improving fracture healing outcomes, offering a promising avenue for future orthopedic interventions.