Assessing the Efficacy of Autogenous Bone Marrow Injections in Managing Delayed Union and Non-union in Long Bone Fractures

Abstract

Background:

Fracture healing complications, including delayed union and non-union, pose significant challenges in orthopedic practice. Percutaneous autologous bone marrow injection has emerged as a promising therapeutic approach for managing these complications by leveraging the regenerative potential of bone marrow-derived stem cells. This study aimed to assess the efficacy of this technique in promoting fracture healing in patients with delayed and non-union long bone fractures.

Methods:

A prospective study was conducted at Saveetha Medical College and Hospital from January 2021 to January 2022, involving 30 patients with delayed and non-union long bone fractures. Patients underwent percutaneous autologous bone marrow injection under regional anaesthesia, with follow-up assessments at 1, 3, 6 months, and 1 year. Clinical data and radiographic evidence were analysed to evaluate treatment outcomes, including fracture healing rates, pain relief, and functional recovery.

Results:

All 30 patients achieved successful clinical and radiological union following percutaneous autologous bone marrow injection. The mean time until radiological appearance of callus was 6.4 weeks, with clinical union achieved within a mean of 7.33 weeks. Positive functional outcomes were observed in all patients, indicating successful restoration of limb function and overall patient well-being. No complications or adverse events were reported during the study period.

 Conclusion:

Percutaneous autologous bone marrow injection demonstrates efficacy in promoting fracture healing and restoring functional outcomes in patients with delayed and non-union long bone fractures. The technique offers a minimally invasive alternative to traditional treatment modalities, with rapid healing response and favourable patient outcomes.