Investigation Of Synergistic And Antagonistic Anti-Asthmatic And Anti-Inflammatory Effects Of Various Phytochemicals Found In Araucaria Columnaris Leaf Extract In Asthma Models.

Abstract

Having asthma means experiencing constant inflammation in the airways, as this leads to bronchial oversensitivity and problems with blocked airflow. Current medication therapy often ends up having issues such as side effects and not being effective for a long period. In the present experiment, substances from the leaf of Araucaria columnaris are tested to determine any synergistic or antagonistic benefits to asthma and inflammation through use of experimental models. Analysis of the extract with phytochemistry showed it contained flavonoids, terpenoids, phenolic acids, and alkaloids, and each of them has its own bioactivity. By using ovalbumin-induced asthma in mice and LPS-stimulated cultured macrophages, researchers tested changes in airway inflammation, increase of eosinophils, cytokine production, and visible pathological changes. The combinations of some phytochemicals were able to provide enhanced inflammation control and improved breathing function, but some phytochemicals worked against each other and reduced the benefits of therapy. The study offers fresh understanding of how bioactive substances in Araucaria columnaris could be used in the development of new plant treatments for asthma.