Synthesis, Characterization and Biological activity of 5-(2-aminophenyl)-1,3,4-oxadiazole-2(3H)-thione

Abstract

In the present paper 5-(2-aminophenyl)-1,3,4-oxadiazole-2(3H)-thione was synthesied synthesized from 2-amino benzoic acid (1b) (10 g, 0.073 mol) as the starting material esterified to methyl 2-amino benzoate (2b) in presence of conc. Sulphuric acid, further methyl benzoate refluxed for 5 hrs with hydrazine hydrate in ethanol to get 2-aminobenzohydrazide (3b) (1.51 g, 0.01 mol) further refluxed with carbon disulphide (10 mL) in alkaline medium to get 5-(2-aminophenyl)-1,3,4-oxadiazole-2(3H)-thione (4b). The synthesized 5-(2-aminophenyl)-1,3,4-oxadiazole-2(3H)-thione was further evaluated and are reported.