Neuroprotective Effect of Apigenin in induced Cerebral Ischemia-Reperfusion Injury in Male Mice

Abstract

Background: The main causes of death is ischemic strokes in addition to cerebral ischemia. We have two types of ischemia that might happen: localized and global, that they all influence the central nervous system and can be extremely leading to patient’s disability. In this research, flavonoids are utilized which are consider as a naturally occurring bioactive substance that is present in large amounts in fruits, vegetables, and traditional herbs. Method: An A total of 32 experimental model Swiss Albino male mice at 10 weeks, weighing 28–36 g used in our study were divided into four groups at random method .Sham group, I\R group, I\R+( dimethyl formamide (DMF), act as a vehicle) , I\R with intraperitoneal Apigenin 40mg/kg 1hour before induction of Bilateral Common Carotid Artery Occlusion (BCCAO). The level of All markers utilized in our study ( IL-1β, Bax, Bcl, and F2- isoprostanewere) measured in brain tissue for every research groups. Results; (40mg/kg) Apigenin was significantly diminish the cerebral tissue level of IL-1β, Bax, and F2-isoprostane and significantly increased Bcl levels when compared to I\R and I\R with vehicle groups. Conclusions; Treatment with flavonoids such as Apigenin has a neuroprotective effect due to its anti-inflammatory, anti-oxidant, and anti-apoptotic properties against injury caused by ischemia.