Polyherbal Formulation For Ovarian Cancer: Synergistic Effects And Therapeutic Potential

Abstract

Ovarian cancer remains a significant global health challenge, particularly in advanced stages where effective treatments are limited. This study evaluates a polyherbal formulation comprising Centella asiatica, Melia dubia, and Solanum nigrum for its potential as an adjunct therapy for ovarian cancer. Methanolic extracts of these herbs were subjected to phytochemical screening and cytotoxicity assays using PA-1 ovarian cancer cells. The analysis revealed key bioactive compounds, including flavonoids, terpenoids, and phenols, known for their anticancer properties. Cytotoxicity assays demonstrated significant antitumor effects, with Solanum nigrum showing the highest activity. The polyherbal tablet formulation exhibited synergistic cytotoxic effects, suggesting its potential to enhance existing ovarian cancer treatments. These findings highlight the importance of integrating traditional herbal medicine with modern pharmacological approaches. Further studies are needed to confirm the efficacy and safety of this formulation in clinical settings.